Rabbit anti-Human C2  Monoclonal Antibody | anti-C2  antibody

Rabbit anti Human C2  Monoclonal Antibody

Cat. Num. AAA2543863

• Gene Names: C2; CO2; ARMD14
• Reactivity: Human
• Applications: ELISA
• Synonyms: C2 ; Monoclonal Antibody; Rabbit anti Human C2 Monoclonal Antibody; anti-C2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 577

• Applicable Applications for anti-C2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human C2. The detection limit for Human C2 is 0.0049 ng/well.
• Immunogen: Recombinant Human C2 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human complement component 2 (rh C2; Met 1-Leu 752; NP_000054.2).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-C2  antibody

Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides catalytic activity for the C3 and C5 convertases of the classical and lectin pathways of human complement. C4b and C2 was investigated by surface plasmon resonance. C2a containing a serine protease domain combines with complement component C4b to form the C3 convertase C4b2a which is responsible for C3 activation, and leads to the stimulation of adaptive immune responses via Lectin pathway. C2 bound to C4b is cleaved by classical (C1s) or lectin (MASP2) proteases to produce C4bC2a. C2 has the same serine protease domain as C4bC2a but in an inactive zymogen-like conformation, requiring cofactor-induced conformational change for activity. Deficiency of C2 (C2D) is the most common genetic deficiency of the complement system, and two types of C2D have been recognized in the context of specific MHC haplotypes. C2D in human is reported to increase susceptibility to infection, and is associated with certain autoimmune diseases, such as rheumatological disorders.

NCBI and Uniprot Product Information

• NCBI GI #: 15277207
• NCBI GeneID: 717
• Molecular Weight: 69,444 Da
• NCBI Official Full Name: C2, partial
• NCBI Official Synonym Full Names: complement C2
• NCBI Official Symbol: C2
• NCBI Official Synonym Symbols: CO2; ARMD14
• NCBI Protein Information: complement C2
• UniProt Protein Name: Complement C2
• UniProt Gene Name: C2
• UniProt Entry Name: CO2_HUMAN

NCBI Description

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

Uniprot Description

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.