C Reactive Protein (CRP) Monoclonal Antibody | anti-CRP antibody

MAb to CRP

Cat. Num. AAA311541

• Gene Names: CRP; PTX1; MGC88244; MGC149895
• Applications: ELISA, Immunohistochemistry
• Purity: >90% pure (SDS-PAGE). Protein A chromatography
• Synonyms: C Reactive Protein (CRP); Monoclonal Antibody; MAb to CRP; Monoclonal Antibody to Human C Reactive Protein (CRP); anti-CRP antibody

• Host: Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice; Source: Ascites
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: C7
• Specificity: C Reactive Protein (CRP); Human CRP. Recognizes antigen both in the presence and in the absence (samples containing EDTA) of Ca2+.
• Purity/Purification: >90% pure (SDS-PAGE). Protein A chromatography
• Form/Format: Purified, Liquid
• Concentration: 5.4mg/ml (Sigma protein assay kit); Titer: >10^-6 (ELISA) (varies by lot)
• Sequence Length: 224

• Applicable Applications for anti-CRP antibody: EIA/ELISA, Immunohistochemistry - Paraffin, Immunoassay Antibody Pairs
• Application Notes: CRP immunoassay, coating antibody and immunoaffinity purification. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be ex
• Immunogen: Purified human CRP
• Affinity Constant: Not determined
• Buffer: PBS, pH 7.4
• Preservative: 0.1% Sodium azide
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
• Preparation and Storage: Store at 2 to 8 degree C.

Product Categories/Family for anti-CRP antibody

Monoclonal Antibodies to Proteins and Bioactive Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 117486
• NCBI GeneID: 1401
• UniProt Accession #: P02741; Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0; Q5VVP7
• Molecular Weight: 25,039 Da
• NCBI Official Full Name: C-reactive protein
• NCBI Official Synonym Full Names: C-reactive protein, pentraxin-related
• NCBI Official Symbol: CRP
• NCBI Official Synonym Symbols: PTX1; MGC88244; MGC149895
• NCBI Protein Information: C-reactive protein; pentraxin 1; OTTHUMP00000033307
• UniProt Protein Name: C-reactive protein
• Protein Family: Cryparin
• UniProt Gene Name: CRP
• UniProt Synonym Gene Names: PTX1
• UniProt Entry Name: CRP_HUMAN

NCBI Description

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]

Uniprot Description

Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Cofactor: Binds 2 calcium ions per subunit.

Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular location: Secreted.

Tissue specificity: Found in plasma.

Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6.

Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.

Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain.

Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15