Testing Data
(Figure 1. The basic principle of BiTE cell killing assay. The BiTE molecule can effectively bring T cells to tumor target cells and stimulate tumor cell killing activity of T cells.)
Rabbit anti-Human BCMA bispecific Monoclonal Antibody | anti-BCMA antibody
Anti-BCMA bispecific antibody (DM16)
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Purified from cell culture supernatant by affinity chromatography
Synonyms
BCMA bispecific; Monoclonal Antibody; Anti-BCMA bispecific antibody (DM16); TNFRSF17; anti-BCMA antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit scfv
Clone Number
DM16
Purity/Purification
Purified from cell culture supernatant by affinity chromatography
Form/Format
Liquid; 0.1% Procline 300; 50% Glycerol; PBS, pH7.4; 0.1% BSA
Applicable Applications for anti-BCMA antibody
Flow Cytometry (FC/FACS), MM Tumor cell killing
Application Notes
FC:FACS: 1:100
Immunogen
Recombinant human BCMA (Met1-Ala54) produced by using human HEK293 cells
Reconstitution
Reconstitute with deionized water
Preservative
0.1% Procline 300
Constituents
50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preparation and Storage
Store at -20 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Shipping: Blue Ice
Testing Data
(Figure 1. The basic principle of BiTE cell killing assay. The BiTE molecule can effectively bring T cells to tumor target cells and stimulate tumor cell killing activity of T cells.)
Testing Data
(Figure 1. The basic principle of BiTE cell killing assay. The BiTE molecule can effectively bring T cells to tumor target cells and stimulate tumor cell killing activity of T cells.)
Testing Data
(Figure 2. A: The scheme of Anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase), were incubated with freshly isolated human PBMC, and different concentration of BiTE antibodies constructed from rabbit Anti-Human BCMA/TNFRSF17 Clone DM16 (red line), or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation, the viable NCI-H929 tumor cells were measured by luciferase activity assay.)
Testing Data
(Figure 2. A: The scheme of Anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase), were incubated with freshly isolated human PBMC, and different concentration of BiTE antibodies constructed from rabbit Anti-Human BCMA/TNFRSF17 Clone DM16 (red line), or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation, the viable NCI-H929 tumor cells were measured by luciferase activity assay.)
Related Product Information for anti-BCMA antibody
BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody, and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Product Categories/Family for anti-BCMA antibody
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Product Notes
The BCMA (Catalog #AAA188026) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-BCMA bispecific antibody (DM16) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BCMA bispecific can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), MM Tumor cell killing. FC:FACS: 1:100. Researchers should empirically determine the suitability of the BCMA for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BCMA bispecific, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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