Western Blot (WB)
(Western Blot detection against Immunogen (36.74kD).)
Mouse anti-Human BCL9 Monoclonal Antibody | anti-BCL9 antibody
BCL9 (B-cell CLL/Lymphoma 9 Protein, B-cell Lymphoma 9 Protein, Bcl-9, Protein Legless Homolog)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunofluorescence: 10ug/ml
Western Blot (WB)
(Western Blot detection against Immunogen (36.74kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (36.74kD).)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to BCL9 on HeLa cell. [antibody concentration 10ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of monoclonal antibody to BCL9 on HeLa cell. [antibody concentration 10ug/ml].)
Testing Data
(Detection limit for recombinant GST tagged BCL9 is ~0.03ng/ml as a capture antibody.)
Testing Data
(Detection limit for recombinant GST tagged BCL9 is ~0.03ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity
By similarity. Ref.4
Subunit structure: Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the interaction with PYGO1 increases PYGO1 affinity to histone H3 methylated at 'Lys 4'. Ref.11
Subcellular location: Nucleus
By similarity.
Tissue specificity: Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood.
Involvement in disease: A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies.
Sequence similarities: Belongs to the BCL9 family.
Caution: It is uncertain whether Met-1 or Met-27 is the initiator.
Sequence caution: The sequence CAA73942.1 differs from that shown. Reason: Frameshift at position 1391.
Research Articles on BCL9
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Product Notes
The BCL9 bcl9 (Catalog #AAA649509) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The BCL9 (B-cell CLL/Lymphoma 9 Protein, B-cell Lymphoma 9 Protein, Bcl-9, Protein Legless Homolog) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BCL9 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence, ELISA and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the BCL9 bcl9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: DDDSPPARSP NLPSMNNMPG MGINTQNPRI SGPNPVVPMP TLSPMGMTQP LSHSNQMPSP NAVGPNIPPH GVPMGPGLMS HNPIMGHGSQ EPPMVPQGRM. It is sometimes possible for the material contained within the vial of "BCL9, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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