NCBI and Uniprot Product Information
NCBI Description
beta subunit of rat liver ATP synthase [RGD, Feb 2006]
Uniprot Description
ATP5B: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase alpha/beta chains family.
Protein type: Energy Metabolism - oxidative phosphorylation; Hydrolase; EC 3.6.3.14; Mitochondrial
Cellular Component: cell surface; membrane; mitochondrion; mitochondrial membrane; proton-transporting ATP synthase complex, catalytic core F(1); mitochondrial inner membrane; plasma membrane; nucleus; myelin sheath; mitochondrial proton-transporting ATP synthase complex
Molecular Function: lipoprotein receptor activity; MHC class I protein binding; ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; calcium ion binding; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding
Biological Process: ATP metabolic process; osteoblast differentiation; receptor-mediated endocytosis; proton transport; ATP synthesis coupled proton transport; substrate-bound cell migration, cell release from substrate; ATP biosynthetic process; regulation of intracellular pH; ATP hydrolysis coupled proton transport; angiogenesis; lipid metabolic process
Research Articles on Atp5b
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Product Notes
The Atp5b atp5b (Catalog #AAA6241842) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ATP Synthase, beta (AP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ATP Synthase, beta can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the Atp5b atp5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATP Synthase, beta, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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