Western Blot (WB)
(Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody at 1:100, 1:250, 1:500, and 1:1000.)
Mouse anti-Rat, Mouse ASIC1 Monoclonal Antibody | anti-Asic1 antibody
ASIC1 Antibody: ATTO 594
Western Blot (WB)
(Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody at 1:100, 1:250, 1:500, and 1:1000.)
Western Blot (WB)
(Western Blot analysis of Rat brain lysates showing detection of ASIC1 protein using Mouse Anti-ASIC1 Monoclonal Antibody, Clone S271-44. Primary Antibody: Mouse Anti-ASIC1 Monoclonal Antibody at 1:100, 1:250, 1:500, and 1:1000.)
Scientific Background: Acid sensing ion channel ASIC1, also designated ACCN2, BNAC2 and ASIC1a, is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety.
NCBI and Uniprot Product Information
Uniprot Description
ASIC1: non-voltage-gated amiloride-sensitive cation channel permeable for sodium, potassium and lithium. A member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Expressed in most if not all brain neurons.
Protein type: Membrane protein, integral; Channel, cation; Transporter; Transporter, ion channel; Membrane protein, multi-pass
Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; integral to membrane; dendritic spine; synapse; dendritic shaft
Molecular Function: amiloride-sensitive sodium channel activity; monovalent inorganic cation transmembrane transporter activity; protein binding; ion gated channel activity; ion channel activity; cation channel activity; sodium channel activity
Biological Process: regulation of membrane potential; transport; calcium ion transport; sodium ion transport; monovalent inorganic cation transport; sensory perception of sour taste; ion transport; response to acidity; memory; associative learning; cation transport; negative regulation of neurotransmitter secretion
Research Articles on Asic1
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Product Notes
The Asic1 asic1 (Catalog #AAA803822) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ASIC1 Antibody: ATTO 594 reacts with Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ASIC1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Western Blot (WB), Immunohistochemistry (IHC). 1:1000 WB. Researchers should empirically determine the suitability of the Asic1 asic1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASIC1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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