Testing Data
Mouse anti-Human Angiotensin Converting Enzyme 2, Ectodomain Monoclonal Antibody | anti-Ace2 antibody
Angiotensin Converting Enzyme 2, Ectodomain (ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, DKFZP434A014, EC 3.4.17, OTTHUMP00000022963)
IP: 25ug/ml conditioned cell culture medium spiked with recomninant human ACE-2.
Optimal dilutions to be determined by the researcher.
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
enzyme peptidyl-dipeptidase; mouse homolog has a role in regulation of cardiac contractility and regulating Angiotensin 1 and 2 levels [RGD]
Uniprot Description
Function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. Ref.2
Catalytic activity: Angiotensin II + H2O = angiotensin-1-7 + L-phenylalanine.
Cofactor: Binds 1 zinc ion per subunit
By similarity.Binds 1 chloride ion per subunit
Enzyme regulation: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril, enalaprilat. Ref.3
Subcellular location: Processed angiotensin-converting enzyme 2: Secreted
By similarity Ref.3. Cell membrane; Single-pass type I membrane protein
By similarity Ref.3.
Tissue specificity: Expressed in heart, kidney and forebrain. In testis, expression is restricted to Leydig cells. In heart, expressed in endothelial cells from small and large arteries, arterial smooth muscle cells, and myocytes (at protein level). Ubiquitously expressed, with highest levels in ileum, bladder and lung. Ref.3 Ref.4 Ref.5
Induction: Down-regulated in hypertensive animals. Up-regulated after myocardial infarction. Ref.2 Ref.3 Ref.4
Post-translational modification: Glycosylated. Ref.3
Miscellaneous: In contrast to its human and palm-civet orthologs, does not interact with SARS-CoV spike glycoprotein.
Sequence similarities: Belongs to the peptidase M2 family.
Research Articles on Ace2
Similar Products
Product Notes
The Ace2 ace2 (Catalog #AAA606348) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Angiotensin Converting Enzyme 2, Ectodomain (ACE2, ACE-2, ACE-related Carboxypeptidase, Angiotensin Converting Enzyme Homolog, ACEH, DKFZP434A014, EC 3.4.17, OTTHUMP00000022963) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Angiotensin Converting Enzyme 2, Ectodomain can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP). WB: 2ug/ml NS0 mouse myeloma cell line and human kidney tissue. IP: 25ug/ml conditioned cell culture medium spiked with recomninant human ACE-2. Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the Ace2 ace2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Angiotensin Converting Enzyme 2, Ectodomain, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
