Western Blot (WB)
(Western Blot analysis of pig spleen tissue using ALOX5 Monoclonal Antibody at dilution of 1:2000)
Mouse anti-Human, Pig ALOX5 Monoclonal Antibody | anti-ALOX5 antibody
ALOX5 Monoclonal Antibody
IHC: 1:100-1:400
Western Blot (WB)
(Western Blot analysis of pig spleen tissue using ALOX5 Monoclonal Antibody at dilution of 1:2000)
Western Blot (WB)
(Western Blot analysis of pig spleen tissue using ALOX5 Monoclonal Antibody at dilution of 1:2000)
NCBI and Uniprot Product Information
Observed Molecular Weight: 78kDa
NCBI Description
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Description
5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.
Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q11.21
Cellular Component: cytosol; extracellular region; extracellular space; ficolin-1-rich granule lumen; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm; secretory granule lumen
Molecular Function: arachidonate 5-lipoxygenase activity; iron ion binding; protein binding
Biological Process: leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production involved in inflammatory response; lipoxin metabolic process; lipoxygenase pathway; neutrophil degranulation
Disease: Asthma, Susceptibility To
Research Articles on ALOX5
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Product Notes
The ALOX5 alox5 (Catalog #AAA2549034) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ALOX5 Monoclonal Antibody reacts with Human, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's ALOX5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:1000-1:10000 IHC: 1:100-1:400. Researchers should empirically determine the suitability of the ALOX5 alox5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ALOX5, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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