Mouse AGT Monoclonal Antibody | anti-AGT antibody

AGT (Angiotensinogen (Serpin Peptidase Inhibitor, Clade A, Member 8), ANHU, FLJ92595, FLJ97926, SerpinA8) (Biotin)

Cat. Num. AAA6173532

• Gene Names: AGT; ANHU; hFLT1; SERPINA8
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Purified
• Synonyms: AGT; Monoclonal Antibody; AGT (Angiotensinogen (Serpin Peptidase Inhibitor; Clade A; Member 8); ANHU; FLJ92595; FLJ97926; SerpinA8) (Biotin); Angiotensinogen (Serpin Peptidase Inhibitor; SerpinA8; anti-AGT antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG3,k
• Clone Number: 3C10
• Specificity: Recognizes AGT.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 485

• Applicable Applications for anti-AGT antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: AGT (AAH11519, 1aa-485aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLTGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVSFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
• Conjugate: Biotin
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Immunoperoxidase of monoclonal antibody to AGT on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml])

Immunohistochemistry (IHC)

(Immunoperoxidase of monoclonal antibody to AGT on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml])

Western Blot (WB)

(Western Blot analysis of AGT expression in transfected 293T cell line by AGT monoclonal antibody (M04), clone 3C10.Lane 1: AGT transfected lysate (Predicted MW: 53.1 KDa).Lane 2: Non-transfected lysate.)

Related Product Information for anti-AGT antibody

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq]

Product Categories/Family for anti-AGT antibody

Antibodies; Protease Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 15079348
• NCBI GeneID: 183
• NCBI Official Full Name: Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
• NCBI Official Synonym Full Names: angiotensinogen
• NCBI Official Symbol: AGT
• NCBI Official Synonym Symbols: ANHU; hFLT1; SERPINA8
• NCBI Protein Information: angiotensinogen
• Protein Family: Angiotensinogen

NCBI Description

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]