Mouse ACD Monoclonal Antibody | anti-ACD antibody

ACD (Adrenocortical Dysplasia Homolog (mouse), PIP1, PTOP, TINT1, TPP1) (Biotin)

Cat. Num. AAA6173642

• Gene Names: ACD; PIP1; PTOP; TPP1; TINT1
• Applications: Immunoprecipitation, Western Blot
• Purity: Purified
• Synonyms: ACD; Monoclonal Antibody; ACD (Adrenocortical Dysplasia Homolog (mouse); PIP1; PTOP; TINT1; TPP1) (Biotin); Adrenocortical Dysplasia Homolog (mouse); TPP1; anti-ACD antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 1C11-1A7
• Specificity: Recognizes ACD.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 544

• Applicable Applications for anti-ACD antibody: Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: ACD (AAH16904, 1aa-544aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: MPGRCQSDAAMRVNGPASRAPAGWTSGSLHTGPRAGRPRAQARGVRGRGLLLRPRPAKELPLPRKGGAWAPAGNPGPLHPLGVAVGMAGSGRLVLRPWIRELILGSETPSSPRAGQLLEVLQDAEAAVAGPSHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWEEKEFGFRGTEGRLLLLQDCGVHVQVAEGGAPAEFYLQVDRFSLLPTEQPRLRVPGCNQDLDVQKKLYDCLEEHLSESTSSNAGLSLSQLLDEMREDQEHQGALVCLAESCLTLEGPCTAPPVTHWAASRCKATGEAVYTVPSSMLCISENDQLILSSLGPCQRTQGPELPPPDPALQDLSLTLIASPPSSPSSSGTPALPGHMSSEESGTSISLLPALSLAAPDPGQRSSSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPRSHVPSPHQALVTRPQKPSLEFKEFVGLPCKNRPPFPRTGATRGAQEPCSVWEPPKRHRDGSAFQYEYEPPCTSLCARVQAARLPPQLMAWALHFLMDAQPGSEPTPM
• Conjugate: Biotin
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunoprecipitation (IP)

(Immunoprecipitation of ACD transfected lysate using anti-ACD monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with ACD MaxPab rabbit polyclonal antibody.)

Western Blot (WB)

(Western Blot analysis of ACD expression in transfected 293T cell line by ACD monoclonal antibody (M01), clone 1C11-1A7.Lane 1: ACD transfected lysate (Predicted MW: 57.7 KDa).Lane 2: Non-transfected lysate.)

Testing Data

(Detection limit for recombinant GST tagged ACD is 1 ng/ml as a capture antibody.)

Related Product Information for anti-ACD antibody

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq]

Product Categories/Family for anti-ACD antibody

Antibodies; Telomere/Telomerase

NCBI and Uniprot Product Information

• NCBI GI #: 16877291
• NCBI GeneID: 65057
• NCBI Official Full Name: ACD protein
• NCBI Official Synonym Full Names: ACD shelterin complex subunit and telomerase recruitment factor
• NCBI Official Symbol: ACD
• NCBI Official Synonym Symbols: PIP1; PTOP; TPP1; TINT1
• NCBI Protein Information: adrenocortical dysplasia protein homolog
• Protein Family: ACD11 homolog protein

NCBI Description

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]