Mouse 26S proteasome non-ATPase regulatory subunit 11 Monoclonal Antibody | anti-PSMD11 antibody

Mouse Anti Human 26S proteasome non-ATPase regulatory subunit 11

Cat. Num. AAA140209

• Gene Names: Psmd11; S9; P44.5; C78232; 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik
• Applications: ELISA, Western Blot
• Purity: PSMD11 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: 26S proteasome non-ATPase regulatory subunit 11; Monoclonal Antibody; Mouse Anti Human 26S proteasome non-ATPase regulatory subunit 11; PSMD11 Antibody; Mouse Anti Human; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit p44.5; PSMD11; S9; Rpn6; p44.5; MGC3844; anti-PSMD11 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 heavy chain and kappa light chain
• Clone Number: PAT1F4AT
• Purity/Purification: PSMD11 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 416

• Applicable Applications for anti-PSMD11 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: PSMD11 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:250 ~ 1000. Recommended starting dilution is 1:250.
• Immunogen: Anti-human PSMD11 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PSMD11 amino acids 1-422 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-PSMD11 antibody

Introduction: The 26S proteasome is a multicatalytic proteinase complex with a well ordered structure composed of two complexes- a 20S core and a 19S regulator. PSMD11 is a non-ATPase subunit of the 19S regulator. The 20S core is composed of four rings of 28 non-identical subunits; two rings are composed of 7 alpha subunits and two rings are composed of 7 beta subunits. The 19S regulator is composed of a base that contains six ATPase subunits and two non-ATPase subunits, and a lid that contains up to ten non-ATPase subunits. Proteasomes are spread throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An indispensable function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

Product Categories/Family for anti-PSMD11 antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme

NCBI and Uniprot Product Information

• NCBI GI #: 33585718
• NCBI GeneID: 69077
• Molecular Weight: 47,437 Da
• NCBI Official Full Name: Psmd11 protein, partial
• NCBI Official Synonym Full Names: proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
• NCBI Official Symbol: Psmd11
• NCBI Official Synonym Symbols: S9; P44.5; C78232; 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 11
• Protein Family: 26S proteasome non-ATPase regulatory
• UniProt Gene Name: Psmd11
• UniProt Entry Name: PSD11_MOUSE

Uniprot Description

PSMD11: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Belongs to the proteasome subunit S9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Proteasome complex; Protease

Cellular Component: proteasome complex; membrane; proteasome regulatory particle; nucleus

Molecular Function: protein binding

Biological Process: ubiquitin-dependent protein catabolic process; stem cell differentiation; proteasome assembly