Monkey Apoptosis-inducing factor 2 (AIFM2) ELISA Kit | AIFM2 elisa kit
Monkey Apoptosis-inducing factor 2 (AIFM2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
Uniprot Description
AIFM2: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. Belongs to the FAD-dependent oxidoreductase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Apoptosis; EC 1.-.-.-; Mitochondrial; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: extracellular space; mitochondrial outer membrane; mitochondrion; cytoplasm; integral to membrane; lipid particle; cytosol
Molecular Function: FAD binding; DNA binding; NADH dehydrogenase (ubiquinone) activity; electron-transferring-flavoprotein dehydrogenase activity
Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis