Modifier of mdg4 (mod (mdg4)) Recombinant Protein | mod(mdg4) recombinant protein

Recombinant Drosophila melanogaster Modifier of mdg4 (mod (mdg4)), partial

• Gene Names: mod(mdg4); BcDNA:GH07769; BcDNA:SD03001; bpd; CG15500; CG15501; CG15802; CG18151; CG32491; CG7836; CG7859; CG8076; DmelCG32491; doom; Doom; E(var)129; E(var)3-93D; E(var)93D; E-(var)3-93D; E-var(3)1; E-var(3)3; l(3)03852; l(3)j2B7; l(3)L3101; mdg4; mnm; mnn; mod; mo
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Modifier of mdg4 (mod (mdg4)); Recombinant Drosophila melanogaster Modifier of mdg4 (mod (mdg4)); partial; mod(mdg4) recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 520

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 161078472
• NCBI GeneID: 49228
• NCBI Accession #: NP_001097856.1
• NCBI GenBank Nucleotide #: NM_001104386.2
• UniProt Accession #: Q86B87; P91932; Q24099; Q24100; Q24101; Q24482; Q24483; Q86B84; Q86B85; A1A725; A8JR64; A8JR66
• Molecular Weight: 57,814 Da
• NCBI Official Full Name: modifier of mdg4, isoform AA
• NCBI Official Synonym Full Names: modifier of mdg4
• NCBI Official Symbol: mod(mdg4)
• NCBI Official Synonym Symbols: BcDNA:GH07769; BcDNA:SD03001; bpd; CG15500; CG15501; CG15802; CG18151; CG32491; CG7836; CG7859; CG8076; DmelCG32491; doom; Doom; E(var)129; E(var)3-93D; E(var)93D; E-(var)3-93D; E-var(3)1; E-var(3)3; l(3)03852; l(3)j2B7; l(3)L3101; mdg4; mnm; mnn; mod; mo
• NCBI Protein Information: CG32491 gene product from transcript CG32491-RAF
• UniProt Protein Name: Modifier of mdg4
• Protein Family: Modifier of mdg4
• UniProt Gene Name: mod(mdg4)

Uniprot Description

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional. Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents. Isoform H also plays a role in apoptotic regulatory pathways.