Matrix metalloproteinase-14 (MMP14) Recombinant Protein | MMP14 recombinant protein
Recombinant Bovine Matrix metalloproteinase-14 (MMP14), partial
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Matrix metalloproteinase-14 (MMP14); Recombinant Bovine Matrix metalloproteinase-14 (MMP14); partial; MMP14 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
111-541
Sequence
YAIQGLKWQH NEITFCIQNY TPNVGEYATF EAIRKAFRVW ESATPLRFRE VPYAYIREGH EKQADIMIFF AEGFHGDSTP FDGEGGFLAH AYFPGPNIGG DTHFDSAEPW TVRNEDLNGN DIFLVAVHEL GHALGLEHSN DPSAIMAPFY QWMDTENFVL PDDDRRGIQQ LYGSKSGSPT KMPPQPRTTS RPSVPDKPKN PTYGPNICDG NFDTVAMLRG EMFVFKERWF WRVRKNQVMD GYPMPIGQFW RGLPASINTA YERKDGKFVF FKGDKHWVFD EASLEPGYPK HIKELGRGLP TDRIDAALFW MPNGKTYFFR GNKYYRFNEE LRIVESEYPK NIKVWEGIPE SPRGSFMGSD EVFTYFYKGN KYWKFNNQKL KVEPGYPKSA LRDWMGCPSS GGQPDEGTEE ETEVIIIEVD EEGSGAVSAA A
Sequence Length
431
Species
Bovine
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for MMP14 recombinant protein
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, This protein is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
65,883 Da
NCBI Official Full Name
matrix metalloproteinase-14
NCBI Official Synonym Full Names
matrix metallopeptidase 14
NCBI Official Symbol
MMP14
NCBI Protein Information
matrix metalloproteinase-14
UniProt Protein Name
Matrix metalloproteinase-14
Protein Family
UniProt Gene Name
MMP14
UniProt Synonym Gene Names
MMP-14; MT-MMP 1; MTMMP1; MT1-MMP; MT1MMP
Uniprot Description
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
Research Articles on MMP14
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Product Notes
The MMP14 mmp14 (Catalog #AAA1296590) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 111-541. The amino acid sequence is listed below: YAIQGLKWQH NEITFCIQNY TPNVGEYATF EAIRKAFRVW ESATPLRFRE VPYAYIREGH EKQADIMIFF AEGFHGDSTP FDGEGGFLAH AYFPGPNIGG DTHFDSAEPW TVRNEDLNGN DIFLVAVHEL GHALGLEHSN DPSAIMAPFY QWMDTENFVL PDDDRRGIQQ LYGSKSGSPT KMPPQPRTTS RPSVPDKPKN PTYGPNICDG NFDTVAMLRG EMFVFKERWF WRVRKNQVMD GYPMPIGQFW RGLPASINTA YERKDGKFVF FKGDKHWVFD EASLEPGYPK HIKELGRGLP TDRIDAALFW MPNGKTYFFR GNKYYRFNEE LRIVESEYPK NIKVWEGIPE SPRGSFMGSD EVFTYFYKGN KYWKFNNQKL KVEPGYPKSA LRDWMGCPSS GGQPDEGTEE ETEVIIIEVD EEGSGAVSAA A. It is sometimes possible for the material contained within the vial of "Matrix metalloproteinase-14 (MMP14), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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