Cyclic GMP-AMP synthase (CGAS) Recombinant Protein | CGAS recombinant protein

Recombinant Human Cyclic GMP-AMP synthase (CGAS), partial

Cat. Num. AAA1404646

• Gene Names: MB21D1; cGAS; h-cGAS; C6orf150
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cyclic GMP-AMP synthase (CGAS); Recombinant Human Cyclic GMP-AMP synthase (CGAS); partial; Protein MB21D1; Mab-21 domain-containing protein 1; CGAS recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 161-522. Partial
• Sequence: GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for CGAS recombinant protein

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).

NCBI and Uniprot Product Information

• NCBI GI #: 115511030
• NCBI GeneID: 115004
• NCBI Accession #: NP_612450.2
• NCBI GenBank Nucleotide #: NM_138441.2
• UniProt Accession #: Q8N884; Q14CV6; Q32NC9; Q5SWL0; Q5SWL1; Q96E45; L0L2J9
• Molecular Weight: 58.3 kDa
• NCBI Official Full Name: cyclic GMP-AMP synthase
• NCBI Official Synonym Full Names: Mab-21 domain containing 1
• NCBI Official Symbol: MB21D1
• NCBI Official Synonym Symbols: cGAS; h-cGAS; C6orf150
• NCBI Protein Information: cyclic GMP-AMP synthase; cGAMP synthase; protein MB21D1; mab-21 domain-containing protein 1
• UniProt Protein Name: Cyclic GMP-AMP synthase
• UniProt Gene Name: MB21D1
• UniProt Synonym Gene Names: C6orf150; cGAMP synthase; cGAS; h-cGAS
• UniProt Entry Name: CGAS_HUMAN

Uniprot Description

MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

Protein type: EC 2.7.7.86; Enzyme, cellular metabolism

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: cytosol

Molecular Function: DNA binding; GTP binding; metal ion binding; ATP binding

Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response