MARCKS Related Protein (MARCKSL1) Recombinant Protein | MARCKSL1 recombinant protein

Recombinant MARCKS Related Protein (MARCKSL1)

Cat. Num. AAA2097561

• Gene Names: MARCKSL1; F52; MLP; MRP; MLP1; MACMARCKS
• Reactivity: Human
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: MARCKS Related Protein (MARCKSL1); Recombinant MARCKS Related Protein (MARCKSL1); MLP1; MRP; MLP; F52; MACMARCKS; MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate; MARCKSL1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 195

• Applicable Applications for MARCKSL1 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: N-terminal His and GST Tag
• Buffer Formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1mug
• Fragment: His33~Ala189
• Isoelectric Point: 4.7

SDS-Page

Product Categories/Family for MARCKSL1 recombinant protein

Enzyme & Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 13491174
• NCBI GeneID: 65108
• NCBI Accession #: NP_075385.1
• NCBI GenBank Nucleotide #: NM_023009.6
• UniProt Accession #: P49006; Q5TEE6; Q6NXS5; D3DPQ0
• Molecular Weight: Predicted Molecular Weight: 45.8kDa; Accurate Molecular Weight: 45.8kDa
• NCBI Official Full Name: MARCKS-related protein
• NCBI Official Synonym Full Names: MARCKS like 1
• NCBI Official Symbol: MARCKSL1
• NCBI Official Synonym Symbols: F52; MLP; MRP; MLP1; MACMARCKS
• NCBI Protein Information: MARCKS-related protein
• UniProt Protein Name: MARCKS-related protein
• Protein Family: MARCKS-related protein
• UniProt Gene Name: MARCKSL1
• UniProt Synonym Gene Names: MLP; MRP; Mac-MARCKS; MacMARCKS

NCBI Description

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

Uniprot Description

MLP: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Belongs to the MARCKS family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: cytoplasm; extracellular exosome; plasma membrane

Molecular Function: actin binding; calmodulin binding; protein binding

Biological Process: positive regulation of cell proliferation