Human A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit | ADAM9 elisa kit

Human A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit

Cat. Num. AAA3800805

• Gene Names: ADAM9; MCMP; MDC9; CORD9; Mltng
• Reactivity: Human
• Synonyms: A Disintegrin And Metalloprotease 9 (ADAM9); Human A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit; ADAM9 elisa kit

• Reactivity: Human
• Sequence Length: 712

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 50 pg/ml-800 pg/ml
• Sensitivity: 1 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ADAM9 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofADAM9in the sample, This ADAM9ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusADAM9concentration. The concentration ofADAM9in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 116496893
• NCBI GeneID: 8754
• UniProt Accession #: Q13443
• NCBI Official Full Name: ADAM9 protein
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 9
• NCBI Official Symbol: ADAM9
• NCBI Official Synonym Symbols: MCMP; MDC9; CORD9; Mltng
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 9
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 9
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: ADAM9
• UniProt Synonym Gene Names: KIAA0021; MCMP; MDC9; MLTNG; ADAM 9
• UniProt Entry Name: ADAM9_HUMAN

NCBI Description

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

ADAM9: Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 8p11.22

Cellular Component: extracellular space; focal adhesion; cell surface; basolateral plasma membrane; cytoplasm; integral to membrane

Molecular Function: collagen binding; integrin binding; protein binding; protein kinase C binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; laminin binding; SH3 domain binding

Biological Process: integrin-mediated signaling pathway; positive regulation of keratinocyte migration; extracellular matrix organization and biogenesis; activation of MAPKK activity; cell-matrix adhesion; membrane protein ectodomain proteolysis; response to glucocorticoid stimulus; positive regulation of cell adhesion mediated by integrin; positive regulation of membrane protein ectodomain proteolysis; keratinocyte differentiation; response to manganese ion; collagen catabolic process; extracellular matrix disassembly; PMA-inducible membrane protein ectodomain proteolysis; monocyte activation; response to hydrogen peroxide; positive regulation of protein secretion; transforming growth factor beta receptor signaling pathway; cell-cell adhesion mediated by integrin; cell adhesion mediated by integrin; cell adhesion; response to calcium ion

Disease: Cone-rod Dystrophy 9