Human mitogen-activated protein kinase 7 ELISA Kit | MAPK7 elisa kit
Human Mitogen-activated protein kinase 7, MAPK7 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
ERK5: a protein kinase of the MAPK family. Phosphorylated and activated by MEK5. Involved in the signaling processes downstream of various receptors including receptor tyrosine kinases and G protein-coupled receptors. Translocates to cell nucleus in response to extracelluar signals, where it regulates gene expression by phosphorylating various transcription factors. Mouse knockout shows a role in development and integrity of blood vessels. May block apoptosis in endothelial cells. Required for transduction of EGF growth signal, constitutively activated in ErbB2-overexpressing breast cancer, and downstream of activated Mek5 in metastatic prostate cancerFour alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.24; CMGC group; MAPK family; ERK subfamily; MAPK/ERK subfamily
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: nucleoplasm; PML body; cytoplasm; nucleus; cytosol
Molecular Function: MAP kinase activity; protein binding; mitogen-activated protein kinase binding; ATP binding
Biological Process: nerve growth factor receptor signaling pathway; negative regulation of cAMP catabolic process; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; positive regulation of protein metabolic process; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; cAMP-mediated signaling; cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of heterotypic cell-cell adhesion; MyD88-independent toll-like receptor signaling pathway; negative regulation of NFAT protein import into nucleus; cell cycle; regulation of angiogenesis; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; negative regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of cyclic-nucleotide phosphodiesterase activity
Research Articles on MAPK7
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Product Notes
The Human MAPK7 mapk7 (Catalog #AAA9334823) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334823 ELISA Kit recognizes Human MAPK7. It is sometimes possible for the material contained within the vial of "mitogen-activated protein kinase 7, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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