Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS1493920 at dilution 1:100)
Rabbit anti-Human Mitogen-activated protein kinase 7 Polyclonal Antibody | anti-MAPK7 antibody
Rabbit anti-human Mitogen-activated protein kinase 7 polyclonal Antibody(MAPK7)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS1493920 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS1493920 at dilution 1:100)
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS1493920 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS1493920 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
ERK5: a protein kinase of the MAPK family. Phosphorylated and activated by MEK5. Involved in the signaling processes downstream of various receptors including receptor tyrosine kinases and G protein-coupled receptors. Translocates to cell nucleus in response to extracelluar signals, where it regulates gene expression by phosphorylating various transcription factors. Mouse knockout shows a role in development and integrity of blood vessels. May block apoptosis in endothelial cells. Required for transduction of EGF growth signal, constitutively activated in ErbB2-overexpressing breast cancer, and downstream of activated Mek5 in metastatic prostate cancerFour alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Protein type: EC 2.7.11.24; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; MAPK family; ERK subfamily; MAPK/ERK subfamily
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; PML body
Molecular Function: ATP binding; MAP kinase activity; mitogen-activated protein kinase binding; protein binding
Biological Process: cAMP-mediated signaling; cell cycle; cell differentiation; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of cAMP catabolic process; negative regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of MAP kinase activity; negative regulation of NFAT protein import into nucleus; nerve growth factor receptor signaling pathway; peptidyl-serine phosphorylation; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; signal transduction; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Research Articles on MAPK7
Similar Products
Product Notes
The MAPK7 mapk7 (Catalog #AAA1493920) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Mitogen-activated protein kinase 7 polyclonal Antibody(MAPK7) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Mitogen-activated protein kinase 7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the MAPK7 mapk7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mitogen-activated protein kinase 7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
