Rat mitogen-activated protein kinase 3 ELISA Kit | MAPK3 elisa kit
Rat Mitogen-activated protein kinase 3, MAPK3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD, Feb 2006]
Uniprot Description
ERK1: a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.24; Kinase, protein; Protein kinase, CMGC; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily
Cellular Component: Golgi apparatus; focal adhesion; protein complex; mitochondrion; early endosome; nuclear envelope; pseudopodium; caveola; cytosol; microtubule cytoskeleton; nucleoplasm; cytoskeleton; cytoplasm; late endosome; nucleus
Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; phosphotyrosine binding; ATP binding; phosphatase binding; protein kinase activity
Biological Process: DNA damage induced protein phosphorylation; positive regulation of translation; positive regulation of histone phosphorylation; apoptosis; positive regulation of transcription, DNA-dependent; response to toxin; response to lipopolysaccharide; sensory perception of pain; protein amino acid phosphorylation; BMP signaling pathway; response to exogenous dsRNA; regulation of transcription factor activity; lipopolysaccharide-mediated signaling pathway; arachidonic acid metabolic process; protein complex assembly; transcription, DNA-dependent; MAPKKK cascade; regulation of stress-activated MAPK cascade; organ morphogenesis; nuclear translocation of MAPK; peptidyl-serine phosphorylation; cartilage development; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; response to DNA damage stimulus; phosphorylation; regulation of cytoskeleton organization and biogenesis
Research Articles on MAPK3
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Product Notes
The Rat MAPK3 mapk3 (Catalog #AAA9342063) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342063 ELISA Kit recognizes Rat MAPK3. It is sometimes possible for the material contained within the vial of "mitogen-activated protein kinase 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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