Western Blot (WB)
(Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies).)
Rabbit anti-Human EIF2AK4 Polyclonal Antibody | anti-EIF2AK4 antibody
EIF2AK4, NT (9G11) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, GCN2-like Protein, KIAA1338)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Western Blot (WB)
(Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies).)
Western Blot (WB)
(Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies).)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
NCBI and Uniprot Product Information
NCBI Description
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM]
Uniprot Description
GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Translation; Protein kinase, Other; EC 2.7.11.1; Other group; PEK family; GCN2 subfamily
Chromosomal Location of Human Ortholog: 15q15.1
Molecular Function: protein serine/threonine kinase activity; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity
Biological Process: unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation
Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive
Research Articles on EIF2AK4
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Product Notes
The EIF2AK4 eif2ak4 (Catalog #AAA624590) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EIF2AK4, NT (9G11) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, GCN2-like Protein, KIAA1338) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EIF2AK4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the EIF2AK4 eif2ak4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EIF2AK4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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