Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Active Protein | FGFRL1 active protein

Recombinant Human Fibroblast Growth Factor Receptor-Like 1 (FGFRL1), Partial

Cat. Num. AAA7114964

• Gene Names: FGFRL1; FHFR; FGFR5
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Fibroblast Growth Factor Receptor-Like 1 (FGFRL1); Recombinant Human Fibroblast Growth Factor Receptor-Like 1 (FGFRL1); Partial; Fibroblast Growth Factor Receptor-Like 1; FGF Receptor-Like Protein 1; FGF Homologous Factor Receptor; FGFR-Like Protein; Fibroblast Growth Factor Receptor 5; FGFR-5; FGFRL1; FGFR5; FHFR; FGFRL1 active protein

• Host: Mammalian Cell
• Specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum Filtered 20 mM Tris-HCl, 150 mM NaCl, pH 8.0
• Sequence Positions: 25-378aa; Extracellular Domain
• Sequence: ARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWP
• Sequence Length: 504

• Species: Human
• Tag: C-terminal 6xHis-tagged
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Biological Activity: The ED50 as determined by its ability to bind Human FGF Basic in functional ELISA is less than 5 ug/ml.
• Subcellular Location: Membrane, Single-Pass Type I Membrane Protein
• Classification: Cytokine
• Subdivision: Growth Factor
• Preparation and Storage: Store at -20 degree C. For extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for FGFRL1 active protein

Relevance: Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) is a single-pass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consists of a 354 amino acid extracellular domain (ECD) with 3 Ig-like C2-type domains, a 21 amino acid transmembrane segment, and a 134 amino acid cytoplasmic domain. FGFR1 expressed in various tissues, preferentially in cartilaginous tissues and pancreas. It highly expressed in the liver, kidney, heart, brain and skeletal muscle, weakly expressed in the lung, small intestine and spleen. FGFRL1 has a negative effect on cell proliferation.

Function: Has a negative effect on cell proliferation.

Product Categories/Family for FGFRL1 active protein

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 51988912
• NCBI GeneID: 53834
• NCBI Accession #: NP_001004356.1
• NCBI GenBank Nucleotide #: NM_001004356.3
• UniProt Accession #: Q8N441
• Molecular Weight: 39.9 kDa
• NCBI Official Full Name: fibroblast growth factor receptor-like 1
• NCBI Official Synonym Full Names: fibroblast growth factor receptor like 1
• NCBI Official Symbol: FGFRL1
• NCBI Official Synonym Symbols: FHFR; FGFR5
• NCBI Protein Information: fibroblast growth factor receptor-like 1
• UniProt Protein Name: Fibroblast growth factor receptor-like 1
• Protein Family: Fibroblast growth factor receptor
• UniProt Gene Name: FGFRL1
• UniProt Synonym Gene Names: FGFR5; FHFR; FGF receptor-like protein 1; FGFR-5
• UniProt Entry Name: FGRL1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FGFRL1: Has a negative effect on cell proliferation.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: Golgi apparatus; transport vesicle; plasma membrane; integral to membrane

Molecular Function: heparin binding; fibroblast growth factor binding; fibroblast growth factor receptor activity

Biological Process: negative regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; protein heterooligomerization; skeletal development; protein homooligomerization

Disease: Wolf-hirschhorn Syndrome