Rabbit FGFRL1 Polyclonal Antibody | anti-FGFRL1 antibody

FGFRL1 Polyclonal Antibody

Cat. Num. AAA2518945

• Gene Names: FGFRL1; FHFR; FGFR5
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: FGFRL1; Polyclonal Antibody; FGFRL1 Polyclonal Antibody; FHFR; FGFR5; anti-FGFRL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.6mg/mL (varies by lot)
• Sequence Length: 504

• Applicable Applications for anti-FGFRL1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:200-1:1000; IHC: 1:100-1:300
• Immunogen: Recombinant protein of human FGFRL1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of NIH/3T3 cell and Human placenta tissue, lovo cell using FGFRL1 Polyclonal Antibody at dilution of 1:400)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer using FGFRL1 Polyclonal Antibody at dilution of 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer using FGFRL1 Polyclonal Antibody at dilution of 1:40)

Related Product Information for anti-FGFRL1 antibody

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 51988914
• NCBI GeneID: 53834
• NCBI Accession #: NP_001004358.1
• NCBI GenBank Nucleotide #: NM_001004358.1
• Molecular Weight: 54,537 Da
• NCBI Official Full Name: fibroblast growth factor receptor-like 1
• NCBI Official Synonym Full Names: fibroblast growth factor receptor-like 1
• NCBI Official Symbol: FGFRL1
• NCBI Official Synonym Symbols: FHFR; FGFR5
• NCBI Protein Information: fibroblast growth factor receptor-like 1; FGF homologous factor receptor; FGF receptor-like protein 1; FGFR-5; FGFR-like protein; fibroblast growth factor receptor 5
• UniProt Protein Name: Fibroblast growth factor receptor-like 1
• Protein Family: Fibroblast growth factor receptor
• UniProt Gene Name: FGFRL1
• UniProt Synonym Gene Names: FGFR5; FHFR; FGF receptor-like protein 1; FGFR-5
• UniProt Entry Name: FGRL1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FGFRL1: Has a negative effect on cell proliferation.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: Golgi apparatus; transport vesicle; integral to membrane; plasma membrane

Molecular Function: heparin binding; fibroblast growth factor binding; fibroblast growth factor receptor activity

Biological Process: negative regulation of cell proliferation; fibroblast growth factor receptor signaling pathway; protein heterooligomerization; skeletal development; protein homooligomerization

Disease: Wolf-hirschhorn Syndrome