Trypsin-3 Blocking Peptide | M166 blocking peptide

Trypsin-3 (M166) Peptide

Cat. Num. AAA3004175

• Gene Names: PRSS3; T9; MTG; TRY3; TRY4; PRSS4
• Applications: Blocking
• Purity: Synthetic peptide Trypsin-3 (M166). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Trypsin-3; Trypsin-3 (M166) Peptide; Brain trypsinogen; Mesotrypsinogen; Serine protease 3; Serine protease 4; Trypsin III; Trypsin IV; PRSS4; TRY3; TRY4; PRSS3; M166 blocking peptide

• Specificity: This peptide can be used with studies using MBS3004174 Trypsin-3 (M166) pAb.
• Purity/Purification: Synthetic peptide Trypsin-3 (M166). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 261

• Applicable Applications for M166 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for M166 blocking peptide

In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3 is expressed in the brain in addition to the pancreas.

NCBI and Uniprot Product Information

• NCBI GI #: 342672030
• NCBI GeneID: 5646
• NCBI Accession #: NP_001184026.2
• NCBI GenBank Nucleotide #: NP_001184026.2
• UniProt Accession #: P35030
• NCBI Official Full Name: trypsin-3 isoform 3 preproprotein
• NCBI Official Synonym Full Names: serine protease 3
• NCBI Official Symbol: PRSS3
• NCBI Official Synonym Symbols: T9; MTG; TRY3; TRY4; PRSS4
• NCBI Protein Information: trypsin-3
• UniProt Protein Name: Trypsin-3
• Protein Family: Trypsin
• UniProt Gene Name: PRSS3
• UniProt Synonym Gene Names: PRSS4; TRY3; TRY4
• UniProt Entry Name: TRY3_HUMAN

NCBI Description

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

Uniprot Description

Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.