M1-1 protoxin Recombinant Protein | SckvM1gp1 recombinant protein
Recombinant Saccharomyces cerevisiae killer virus M1 M1-1 protoxin
NCBI and Uniprot Product Information
Uniprot Description
Function: Ionophoric toxin secreted by an infected host and lethal to non-infected sensitive strains. Cell killing is achieved in a receptor-mediated process, requiring initial toxin binding to a cell wall (1->6)-beta-D-glucan and, probably, subsequent transfer to a plasma membrane receptor. K1 toxin disrupts the cell by creating a pore across the target cell membrane. Ref.4
Subunit structure: The secreted toxin contains alpha and beta chains that are linked by three disulfide bonds.
Subcellular location: Secreted. Host membrane; Multi-pass membrane protein
Potential. Note: Pore-forming in target cell
Probable.
Miscellaneous: The killer phenotype requires the presence of two different dsRNA viruses: an L-A helper virus and the toxin-coding (M) killer virus. Killer strains of S.cerevisiae producing the toxin K1 kill sensitive cells but are resistant to their own toxin. The gamma and delta chains may play a role, on there own or as part of the protoxin, in the self-protection of the virus-infected killer yeast (toxin immunity).
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Product Notes
The SckvM1gp1 (Catalog #AAA1019673) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 234-316. The amino acid sequence is listed below: YVYPMCEHGI KASYCMALND AMVSANGNLY GLAEKLFSED EGQWETNYYK LYWSTGQWIM SMKFIEESID NANNDFEGCD TGH. It is sometimes possible for the material contained within the vial of "M1-1 protoxin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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