Latent Transforming Growth Factor Beta Binding Protein 2 Recombinant Protein | LTBP2 recombinant protein

Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2)

Cat. Num. AAA2031216

• Gene Names: LTBP2; WMS3; GLC3D; LTBP3; MSPKA; MSTP031; C14orf141
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Latent Transforming Growth Factor Beta Binding Protein 2; Recombinant Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2); LTBP2 recombinant protein

• Host: Host: E Coli; Source: Prokaryotic expression
• Purity/Purification: >95%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Concentration: 8 (varies by lot)
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SLWDSNNIP ARSGEPPRPL PPAAPRPRGL LGRCYLNTVN GQCANPLLEL TTQEDCCGSV GAFWGVTLCA PCPPRPASPV IENGQLECPQ GYKRLNLTHC QDINECLTLG LCKDAECVNT RGSYLCTCRP GLMLDPSRSR CVSDKAISML QGLCYRSLGP GTCTLPLAQR ITKQICCCSR VGKAWGSECE KCPLPGTEAF REICPAGHGY TYASSDIRLS MRKAEEEELA RPPREQGQRS SGALPGPAER QPLRVVTDTWLEAGTIPDKG DSQAGQVTTS VTHAPAWVTG NATT
• Sequence Length: 1821

• Applicable Applications for LTBP2 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Predicted Molecular Mass: 35.3kDa
• Accurate Molecular Mass (KD): 38kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Tag: two N-terminal Tags, His-tag and T7-tag
• Organism Species: Homo sapiens (Human)
• Fragment: Ser522~Thr814
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

Sequence Information

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 50927279
• NCBI GeneID: 4053
• Molecular Weight: 195,052 Da
• NCBI Official Full Name: Latent transforming growth factor beta binding protein 2
• NCBI Official Synonym Full Names: latent transforming growth factor beta binding protein 2
• NCBI Official Symbol: LTBP2
• NCBI Official Synonym Symbols: WMS3; GLC3D; LTBP3; MSPKA; MSTP031; C14orf141
• NCBI Protein Information: latent-transforming growth factor beta-binding protein 2
• UniProt Protein Name: Latent-transforming growth factor beta-binding protein 2
• Protein Family: Latent-transforming growth factor beta-binding protein
• UniProt Gene Name: LTBP2
• UniProt Synonym Gene Names: C14orf141; LTBP3; LTBP-2
• UniProt Entry Name: LTBP2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]

Uniprot Description

LTBP2: May play an integral structural role in elastic-fiber architectural organization and/or assembly. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. Defects in LTBP2 are the cause of microspherophakia (MCSPH). It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation. Defects in LTBP2 are the cause of Weill-Marchesani syndrome 3 (WMS3). A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and lens abnormalities. Belongs to the LTBP family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix

Molecular Function: heparin binding; protein binding; growth factor binding; calcium ion binding

Biological Process: transforming growth factor beta receptor signaling pathway; protein secretion; protein targeting

Disease: Glaucoma 3, Primary Congenital, D; Microspherophakia And/or Megalocornea, With Ectopia Lentis And With Or Without Secondary Glaucoma; Glaucoma 3, Primary Infantile, B; Weill-marchesani Syndrome 3