U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 Recombinant Protein | LSM4 recombinant protein

Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 Protein (N-6His)

Cat. Num. AAA2553339

• Gene Names: LSM4; GRP; YER112W
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: U6 snRNA-Associated Sm-Like Protein LSm4/LSM4; Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 Protein (N-6His); U6 snRNA-Associated Sm-Like Protein LSm4; Glycine-Rich Protein; GRP; LSM4; LSM4 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris HCl, 100mM NaCl, 1mM DTT, pH 8.0.
• Sequence Positions: Met1-Gln139
• Sequence Length: 139

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for LSM4 recombinant protein

U6 snRNA-associated Sm-like protein LSm4 (LSM4) is a member of the snRNP Sm proteins family. Sm-like proteins contain the Sm sequence motif and are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM4 forms a heteromer with a donut shape. The complexes are involved in various steps of RNA metabolism. LSM4 binds specifically to the 3-terminal U-tract of U6 snRNA. LSM4 contributes RNA protein interactions and structural changes which are essential during ribosomal subunit assembly.

NCBI and Uniprot Product Information

• NCBI GI #: 6912486
• NCBI GeneID: 25804
• NCBI Accession #: NP_036453.1
• NCBI GenBank Nucleotide #: NM_012321.4
• UniProt Accession #: Q9Y4Z0
• Molecular Weight: Molecular Mass: 17.5 kDa; Actual Protein Molecular Mass: 17 kDa
• NCBI Official Full Name: U6 snRNA-associated Sm-like protein LSm4 isoform 1
• NCBI Official Synonym Full Names: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
• NCBI Official Symbol: LSM4
• NCBI Official Synonym Symbols: GRP; YER112W
• NCBI Protein Information: U6 snRNA-associated Sm-like protein LSm4
• UniProt Protein Name: U6 snRNA-associated Sm-like protein LSm4
• Protein Family: U6 snRNA-associated Sm-like protein
• UniProt Gene Name: LSM4
• UniProt Synonym Gene Names: GRP

NCBI Description

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).