Rabbit LSM4 Polyclonal Antibody | anti-LSM4 antibody

LSM4 Antibody

Cat. Num. AAA9611883

• Gene Names: LSM4; GRP; YER112W
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: LSM4; Polyclonal Antibody; LSM4 Antibody; Glycine rich protein; GRP; LSM 4; LSM4 homolog; LSM4 homolog U6 small nuclear RNA associated (S. cerevisiae); LSM4 homolog U6 small nuclear RNA associated; U6 small nuclear RNA associated; U6 snRNA associated Sm like protein 4; U6 snRNA associated Sm like protein; U6 snRNA associated Sm like protein LSm 4; U6 snRNA associated Sm like protein LSm4; YER 112W; YER112W; anti-LSM4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: LSM4 Antibody detects endogenous levels of LSM4.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 139

• Applicable Applications for anti-LSM4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human LSM4.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Nucleus
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from MCF7 cells, using LSM4 Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-LSM4 antibody

Description: Binds specifically to the 3'-terminal U-tract of U6 snRNA.

Subunit Structure: LSm subunits form a heteromer with a doughnut shape.

Similarity: Belongs to the snRNP Sm proteins family.

NCBI and Uniprot Product Information

• NCBI GI #: 6912486
• NCBI GeneID: 25804
• NCBI Accession #: NP_036453.1
• NCBI GenBank Nucleotide #: NP_036453.1
• UniProt Accession #: Q9Y4Z0
• Molecular Weight: Observed: 15 kDa; Predicted: 16 kDa
• NCBI Official Full Name: U6 snRNA-associated Sm-like protein LSm4 isoform 1
• NCBI Official Synonym Full Names: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
• NCBI Official Symbol: LSM4
• NCBI Official Synonym Symbols: GRP; YER112W
• NCBI Protein Information: U6 snRNA-associated Sm-like protein LSm4
• UniProt Protein Name: U6 snRNA-associated Sm-like protein LSm4
• Protein Family: Sm-like protein
• UniProt Gene Name: LSM4
• UniProt Synonym Gene Names: GRP
• UniProt Entry Name: LSM4_HUMAN

NCBI Description

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

LSM4: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.

Protein type: RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; cytosol

Molecular Function: protein binding

Biological Process: RNA splicing; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay