Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) Recombinant Protein | LRPPRC recombinant protein

Recombinant Human Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) , partial

• Gene Names: LRPPRC; LSFC; GP130; LRP130; CLONE-23970
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Leucine-rich PPR motif-containing protein; mitochondrial (LRPPRC); Recombinant Human Leucine-rich PPR motif-containing protein; partial; LRPPRC recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,394

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for LRPPRC recombinant protein

This gene encodes a protein that is leucine-rich and is thought to play a role in regulating the interaction of the cytoskeleton with a variety of cellular processes. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. Transcripts ranging in size from 4.8 to 7.0 kb which result from alternative polyadenylation have been reported for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 31621305
• NCBI GeneID: 10128
• NCBI Accession #: NP_573566.2
• NCBI GenBank Nucleotide #: NM_133259.3
• UniProt Accession #: P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84; A0PJE3; A8K1V1
• Molecular Weight: 157,905 Da
• NCBI Official Full Name: leucine-rich PPR motif-containing protein, mitochondrial
• NCBI Official Synonym Full Names: leucine rich pentatricopeptide repeat containing
• NCBI Official Symbol: LRPPRC
• NCBI Official Synonym Symbols: LSFC; GP130; LRP130; CLONE-23970
• NCBI Protein Information: leucine-rich PPR motif-containing protein, mitochondrial
• UniProt Protein Name: Leucine-rich PPR motif-containing protein, mitochondrial
• Protein Family: Leucine-rich PPR motif-containing protein
• UniProt Gene Name: LRPPRC
• UniProt Synonym Gene Names: LRP130; LRP 130

NCBI Description

This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]

Uniprot Description

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA ().