Leupaxin (LPXN) Recombinant Protein | LPXN recombinant protein

Recombinant Leupaxin (LPXN)

Cat. Num. AAA2086811

• Gene Names: LPXN; LDPL
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Leupaxin (LPXN); Recombinant Leupaxin (LPXN); LDPL; LDLP; LPXN recombinant protein

• Host: E Coli
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 391

• Applicable Applications for LPXN recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Fragment: Met1~Gln205
• Tag: N-terminal His-tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Prokaryotic expression
• Organism Species: Human
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 4.8
• Subcellular Location: Cell Junction. Cell Membrane. Cell projection. Cytoplasm. Membrane. Nucleus.
• Usage: Reconstitute in PBS or others.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for LPXN recombinant protein

Recombinant Protein

NCBI and Uniprot Product Information

• NCBI GI #: 221316659
• NCBI GeneID: 9404
• NCBI Accession #: NP_001137467.1
• NCBI GenBank Nucleotide #: NM_001143995.2
• UniProt Accession #: O60711; Q53FW6; Q6FI07; B2R8B4; B4DV71
• Molecular Weight: 26.3kDa
• NCBI Official Full Name: leupaxin isoform 1
• NCBI Official Synonym Full Names: leupaxin
• NCBI Official Symbol: LPXN
• NCBI Official Synonym Symbols: LDPL
• NCBI Protein Information: leupaxin
• UniProt Protein Name: Leupaxin
• Protein Family: Leupaxin
• UniProt Gene Name: LPXN
• UniProt Synonym Gene Names: LDLP

NCBI Description

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Uniprot Description

leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion. .

Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: cytoplasm; focal adhesion; membrane; nucleus; plasma membrane; podosome

Molecular Function: protein binding; transcription cofactor activity

Biological Process: negative regulation of B cell receptor signaling pathway; negative regulation of cell adhesion; protein complex assembly; signal transduction