Activity
(Assay Data : Sample assay data. For lot-specific data, please refer to the specific datasheet.)
COVID 19 Spike Neutralizing Nanobody (NBX20038) Coronavirus Immunoglobulin | COVID-19 immunoglobulin
Anti-2019-nCoV Spike Protein Neutralizing Nanobody (NBX20038)
Reactivity
2019-nCoV
Applications
ELISA
Synonyms
COVID 19 Spike Neutralizing Nanobody (NBX20038) Coronavirus; Anti-2019-nCoV Spike Protein Neutralizing Nanobody (NBX20038); 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Neutralizing Nanobody (NBX20038); Anti 2019-nCoV Spike Protein Single-domain Antibody; COVID-19 immunoglobulin
Host
Llama
Reactivity
2019-nCoV
Specificity
Recognizes the 2019-nCoV Spike protein. Neutralizing activity validated for wild type Spike protein RBD and RBD (N501Y) variants
Form/Format
Recombinant protein stored in 50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole
Concentration
1.0ug/ul (varies by lot)
Applicable Applications for COVID-19 immunoglobulin
ELISA (EIA)
Application Notes
studying neutralization of SARS-CoV-2
Preparation and Storage
1 year at -20 degree C from date of shipment
Activity
(Assay Data : Sample assay data. For lot-specific data, please refer to the specific datasheet.)
Activity
(Assay Data : Sample assay data. For lot-specific data, please refer to the specific datasheet.)
Activity
(Assay Data : Sample assay data. For lot-specific data, please refer to the specific datasheet.)
Activity
(Assay Data : Sample assay data. For lot-specific data, please refer to the specific datasheet.)
Related Product Information for COVID-19 immunoglobulin
Recombinant Llama VHH for studying neutralization of SARS-CoV-2 and detection of 2019-nCoV Spike Protein.
The severe acute respiratory syndrome related novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). A receptor binding domain (RBD) of S1 can recognize the cell surface receptor and the mutation of RBD could cause higher motility rate (3).
The severe acute respiratory syndrome related novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). A receptor binding domain (RBD) of S1 can recognize the cell surface receptor and the mutation of RBD could cause higher motility rate (3).
Product Categories/Family for COVID-19 immunoglobulin
References
1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.
2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.
3. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235
2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.
3. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235
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Product Notes
The COVID-19 (Catalog #AAA516677) is an Immunoglobulin produced from Llama and is intended for research purposes only. The product is available for immediate purchase. The Anti-2019-nCoV Spike Protein Neutralizing Nanobody (NBX20038) reacts with 2019-nCoV and may cross-react with other species as described in the data sheet. AAA Biotech's COVID 19 Spike Neutralizing Nanobody (NBX20038) Coronavirus can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). studying neutralization of SARS-CoV-2. Researchers should empirically determine the suitability of the COVID-19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COVID 19 Spike Neutralizing Nanobody (NBX20038) Coronavirus, Immunoglobulin" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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