SDS-Page
(Purity: Sample purity data. For lo specific data, please refer to the respective datasheet.)
COVID 19 Spike S1 (delta69-70, Y453F, D614G) Coronavirus Recombinant Protein | COVID-19 recombinant protein
2019-nCoV Spike protein S1 (delta69-70, Y453F, D614G)
Synonyms
COVID 19 Spike S1 (delta69-70; Y453F; D614G) Coronavirus; 2019-nCoV Spike protein S1 (delta69-70; D614G); 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike S1 (delta69-70; 2019-nCoV s1; SARS-CoV-2 spike S1; SARS-CoV-2 S1; novel coronavirus spike s1; nCoV spike s1; coronavirus spike S1.; COVID-19 recombinant protein
Host
CHO cells
Form/Format
Recombinant protein stored in 50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole.
Concentration
0.5ug/ul (varies by lot)
Tag
HIS
Species
SARS-CoV-2
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
SDS-Page
(Purity: Sample purity data. For lo specific data, please refer to the respective datasheet.)
SDS-Page
(Purity: Sample purity data. For lo specific data, please refer to the respective datasheet.)
Activity
(Activity: Sample activity data. for lot-specific data, please refer to the specific datasheet.)
Activity
(Activity: Sample activity data. for lot-specific data, please refer to the specific datasheet.)
Related Product Information for COVID-19 recombinant protein
Recombinant 2019-nCoV Spike protein S1 (delta69-70, Y453F, D614G)(16-685) was expressed in CHO cells using a C-terminal His-tag. The gene accession number is MN908947.
Novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world. The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2)(1). Upon binding of S1 subunit of Spike protein to the host ACE2, TMPRSS2 cleaves at the S1/S2 boundary or within S2 subunit to facilitate the entry of viral genomes into the host cells. SARS-CoV-2 variant comprising Y453F and delta 69-70 mutations has been detected in human cases in Denmark. Y453F mutation associated with the mink infections has mild positive effect on viral binding to host cell. However, D614G and deltaH69/V70 have been considered to enhance viral transmissibility and infectivity, respectively (3, 4).
Novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world. The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2)(1). Upon binding of S1 subunit of Spike protein to the host ACE2, TMPRSS2 cleaves at the S1/S2 boundary or within S2 subunit to facilitate the entry of viral genomes into the host cells. SARS-CoV-2 variant comprising Y453F and delta 69-70 mutations has been detected in human cases in Denmark. Y453F mutation associated with the mink infections has mild positive effect on viral binding to host cell. However, D614G and deltaH69/V70 have been considered to enhance viral transmissibility and infectivity, respectively (3, 4).
Product Categories/Family for COVID-19 recombinant protein
References
1. Lan J, et al: Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature. 2020, 581:215-220.
2. Hou YJ, et al: SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science. 2020, 370 (6523):1464-1468.
3. Kemp SA, et al: Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70. bioRxiv 2020.12.14.422555; doi: https://doi.org/10.1101/2020.12.14.422555
2. Hou YJ, et al: SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science. 2020, 370 (6523):1464-1468.
3. Kemp SA, et al: Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70. bioRxiv 2020.12.14.422555; doi: https://doi.org/10.1101/2020.12.14.422555
NCBI and Uniprot Product Information
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Product Notes
The COVID-19 (Catalog #AAA516680) is a Recombinant Protein produced from CHO cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "COVID 19 Spike S1 (delta69-70, Y453F, D614G) Coronavirus, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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