LIN7C recombinant protein

Recombinant Human LIN7C

Cat. Num. AAA145954

• Gene Names: LIN7C; MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• Purity: Greater than 90.0% as determined by SDS-PAGE
• Synonyms: LIN7C; Recombinant Human LIN7C; LIN7C Human; LIN7C Human Recombinant; LIN-7-C; LIN-7C; MALS-3; MALS3; VELI3; Lin-7 homolog C; Protein lin-7 homolog C; Mammalian lin-seven protein 3; Veli-3; Vertebrate lin-7 homolog 3; LIN7C recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE
• Form/Format: LIN7C protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 30% glycerol.; Sterile filtered colorless solution.
• Sequence: MGCSHHHHHH SSGLVPRGSH MGSMAALGEP VRLERDICRA IELLEKLQRS GEVPPQKLQA LQRVLQSEFC NAVREVYEHV YETVDISSSP EVRANATAKA TVAAFAASEG HSHPRVVELP KTEEGLGFNI MGGKEQNSPI YISRIIPGGI ADRHGGLKRG DQLLSVNGVS VEGEHHEKAV ELLKAAQGKV KLVVRYTPKV LEEMESRFEK MRSAKRRQQT.
• Sequence Length: 197

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for LIN7C recombinant protein

Description: LIN7C Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-197 a.a.) and having a molecular mass of 24.2 kDa. LIN7C is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: LIN7C has a part in establishing and preserving the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. LIN7C forms membrane-associated multiprotein complexes which regulate distribution and recycling of proteins to the appropriate membrane domains.

Product Categories/Family for LIN7C recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; LIN Protein

NCBI and Uniprot Product Information

• NCBI GI #: 8922944
• NCBI GeneID: 55327
• NCBI Accession #: NP_060832.1
• NCBI GenBank Nucleotide #: NM_018362.3
• UniProt Accession #: Q9NUP9
• Molecular Weight: 21,834 Da
• NCBI Official Full Name: protein lin-7 homolog C
• NCBI Official Synonym Full Names: lin-7 homolog C (C. elegans)
• NCBI Official Symbol: LIN7C
• NCBI Official Synonym Symbols: MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• NCBI Protein Information: protein lin-7 homolog C; LIN-7 protein 3; mammalian lin-seven protein 3; veli-3; vertebrate lin-7 homolog 3
• UniProt Protein Name: Protein lin-7 homolog C
• Protein Family: Protein
• UniProt Gene Name: LIN7C
• UniProt Synonym Gene Names: MALS3; VELI3; Lin-7C; MALS-3; Veli-3
• UniProt Entry Name: LIN7C_HUMAN

Uniprot Description

LIN7C: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11p14

Cellular Component: postsynaptic membrane; neuron projection; tight junction; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; synapse; intercellular junction

Molecular Function: protein domain specific binding; cytoskeletal protein binding; PDZ domain binding

Biological Process: asymmetric protein localization; protein transport; exocytosis; neurotransmitter secretion; morphogenesis of an epithelial sheet; maintenance of epithelial cell polarity