LILRB5/CD85c Recombinant Protein | LILRB5 recombinant protein

LILRB5/CD85c Protein, Human, Recombinant (ECD, hFc Tag)

Cat. Num. AAA8122094

• Gene Names: LILRB5; LIR8; CD85C; LIR-8
• Purity: >90% as determined by SDS-PAGE
• Synonyms: LILRB5/CD85c; LILRB5/CD85c Protein; Human; Recombinant (ECD; hFc Tag); Human LILRB5/CD85c/LIR-8 Protein (ECD; Fc Tag); CD85C Protein; LIR-8 Protein; LIR8 Protein; leukocyte immunoglobulin like receptor B5; LILRB5 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly458

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gly 24
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the Human LILRB5 (NP_006831.1)(Met1-Gly458) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for LILRB5 recombinant protein

Background: A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B)(rs12975366: T >C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms.

NCBI and Uniprot Product Information

• NCBI GI #: 5803070
• NCBI GeneID: 10990
• NCBI Accession #: NP_006831.1
• NCBI GenBank Nucleotide #: NM_006840.4
• UniProt Accession #: O75023; Q8N760
• Molecular Weight: 52,969 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily B member 5 isoform 2
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor B5
• NCBI Official Symbol: LILRB5
• NCBI Official Synonym Symbols: LIR8; CD85C; LIR-8
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily B member 5
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 5
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRB5
• UniProt Synonym Gene Names: LIR8; LIR-8
• UniProt Entry Name: LIRB5_HUMAN

NCBI Description

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]