Human Leukocyte immunoglobulin-like receptor subfamily B member 4 ELISA Kit | LILRB4 elisa kit

Human Leukocyte immunoglobulin-like receptor subfamily B member 4 ELISA Kit

Cat. Num. AAA2885434

• Gene Names: LILRB4; ILT3; LIR5; CD85K; ILT-3; LIR-5
• Reactivity: Human
• Synonyms: Leukocyte immunoglobulin-like receptor subfamily B member 4; Human Leukocyte immunoglobulin-like receptor subfamily B member 4 ELISA Kit; CD85 antigen-like family member K; Immunoglobulin-like transcript 3; ILT-3; Leukocyte immunoglobulin-like receptor 5; LIR-5; LILRB4 elisa kit

• Reactivity: Human
• Sequence Length: 448

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.082ng/mL
• Intra-Assay CV: <=6.3%
• Inter-Assay CV: <=9.1%
• Recovery: 105%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 618857484
• NCBI GeneID: 11006
• NCBI Accession #: NP_001265355.2
• NCBI GenBank Nucleotide #: NM_001278426.3
• UniProt Accession #: Q8NHJ6; O15468; O75021; Q6FGQ9; Q8N1C7; Q8NHL5; A8MVL8
• Molecular Weight: 49,397 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor B4
• NCBI Official Symbol: LILRB4
• NCBI Official Synonym Symbols: ILT3; LIR5; CD85K; ILT-3; LIR-5
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily B member 4
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 4
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRB4
• UniProt Synonym Gene Names: ILT3; LIR5; ILT-3; LIR-5
• UniProt Entry Name: LIRB4_HUMAN

NCBI Description

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane; plasma membrane

Molecular Function: antigen binding; protein binding; receptor activity

Biological Process: adaptive immune response; negative regulation of osteoclast differentiation; signal transduction