Rabbit anti-Human IQCB1 Polyclonal Antibody | anti-IQCB1 antibody

IQCB1, ID (IQCB1, KIAA0036, NPHP5, IQ calmodulin-binding motif-containing protein 1, Nephrocystin-5, p53 and DNA damage-regulated IQ motif protein) (PE)

Cat. Num. AAA6310761

• Gene Names: IQCB1; PIQ; NPHP5; SLSN5
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IQCB1; Polyclonal Antibody; ID (IQCB1; KIAA0036; NPHP5; IQ calmodulin-binding motif-containing protein 1; Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein) (PE); p53 and DNA damage-regulated IQ motif protein; anti-IQCB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IQCB1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 465

• Applicable Applications for anti-IQCB1 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 384-411 in the central region of human IQCB1, UniProt Accession #Q15051.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of MBS6003852 in Ramos cell line lysates (35ug/lane). This demonstrates the IQCB1 antibody detected the IQCB1 protein (arrow).)

Related Product Information for anti-IQCB1 antibody

This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-IQCB1 antibody

Antibodies; Calmodulin

References

Hildebrandt, F., et al. J. Am. Soc. Nephrol. 20(1):23-35(2009)Schafer, T., et al. Hum. Mol. Genet. 17(23):3655-3662(2008). Luo, X., et al. Cancer Res. 65(23):10725-10733(2005). le Maire, A., et al. Proteins 59(2):347-355(2005). Mollet, G., et al. Hum. Mol. Genet. 14(5):645-656(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 170014680
• NCBI GeneID: 9657
• NCBI Accession #: NP_001018865.2; NP_001018864.2
• NCBI GenBank Nucleotide #: NP_001018865.2
• UniProt Accession #: Q15051
• NCBI Official Full Name: IQ calmodulin-binding motif-containing protein 1 isoform c
• NCBI Official Synonym Full Names: IQ motif containing B1
• NCBI Official Symbol: IQCB1
• NCBI Official Synonym Symbols: PIQ; NPHP5; SLSN5
• NCBI Protein Information: IQ calmodulin-binding motif-containing protein 1
• UniProt Protein Name: IQ calmodulin-binding motif-containing protein 1
• Protein Family: IQ calmodulin-binding motif-containing protein
• UniProt Gene Name: IQCB1
• UniProt Synonym Gene Names: KIAA0036; NPHP5; PIQ
• UniProt Entry Name: IQCB1_HUMAN

NCBI Description

This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Jan 2016]

Uniprot Description

IQCB1: Involved in ciliogenesis. Defects in IQCB1 are the cause of Senior-Loken syndrome type 5 (SLSN5). SLSN is a renal-retinal disorder, characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q13.33|3q21.1

Cellular Component: nucleoplasm; microtubule cytoskeleton; centrosome; intercellular bridge; photoreceptor outer segment; cytosol; photoreceptor connecting cilium

Molecular Function: calmodulin binding; protein binding; enzyme binding

Biological Process: organelle organization and biogenesis; photoreceptor cell maintenance; cilium biogenesis; maintenance of organ identity

Disease: Senior-loken Syndrome 5