Chemical Structure
(Fig-1: Chemical structure of Poly(I).Poly(C))
Poly(I).Poly ligand
Poly(I).Poly HMW
Applications
Functional Assay
Purity
>=99%
Synonyms
Poly(I).Poly; Poly(I).Poly HMW; Polyinosinic-polycytidylic acid; potassium salt (poly (I: C)); TLR; ligand; tlr3 ligand; Poly(I).Poly(C); TLR ligand; TLR ligands; poly I: C; polyIC; poly(I: C)Polyinosinic-polycytidylic acid [Poly(I: C)]; Poly(I).Poly ligand
Purity/Purification
>=99%
Form/Format
Liquid (1 mg/ml)
Applicable Applications for Poly(I).Poly ligand
Functional Assay
Preparation and Storage
Store the product at 4 degree C for short term and at -20 degree C for long-term storage.
The product is stable for 2 years at -20 degree C.
The product is stable for 2 years at -20 degree C.
Chemical Structure
(Fig-1: Chemical structure of Poly(I).Poly(C))
Chemical Structure
(Fig-1: Chemical structure of Poly(I).Poly(C))
Related Product Information for Poly(I).Poly ligand
Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I: C)- induces pro-inflammatory TNF-alpha and antiviral IFN-beta, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I: C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
Product Categories/Family for Poly(I).Poly ligand
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Product Notes
The Poly(I).Poly (Catalog #AAA669116) is a Ligand and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Poly(I).Poly can be used in a range of immunoassay formats including, but not limited to, Functional Assay. Researchers should empirically determine the suitability of the Poly(I).Poly for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Poly(I).Poly, Ligand" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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