LCP2 recombinant protein

LCP2, 1-533aa, Human, His-tag, Baculovirus

Cat. Num. AAA206756

• Gene Names: LCP2; SLP76; SLP-76
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: LCP2; 1-533aa; Human; His-tag; Baculovirus; Lymphocyte cytosolic protein 2; SLP-76; SLP76; LCP2 recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ADPMALRNVP FRSEVLGWDP DSLADYFKKL NYKDCEKAVK KYHIDGARFL NLTENDIQKF PKLRVPILSK LSQEINKNEE RRSIFTRKPQ VPRFPEETES HEEDNGGWSS FEEDDYESPN DDQDGEDDGD YESPNEEEEA PVEDDADYEP PPSNDEEALQ NSILPAKPFP NSNSMYIDRP PSGKTPQQPP VPPQRPMAAL PPPPAGRNHS PLPPPQTNHE EPSRSRNHKT AKLPAPSIDR STKPPLDRSL APFDREPFTL GKKPPFSDKP SIPAGRSLGE HLPKIQKPPL PPTTERHERS SPLPGKKPPV PKHGWGPDRR ENDEDDVHQR PLPQPALLPM SSNTFPSRST KPSPMNPLPS SHMPGAFSES NSSFPQSASL PPYFSQGPSN RPPIRAEGRN FPLPLPNKPR PPSPAEEENS LNEEWYVSYI TRPEAEAALR KINQDGTFLV RDSSKKTTTN PYVLMVLYKD KVYNIQIRYQ KESQVYLLGT GLRGKEDFLS VSDIIDYFRK MPLLLIDGKN RGSRYQCTLT HAAGYPHHHH HH
• Sequence Length: 533

• Applicable Applications for LCP2 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1ug of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for LCP2 recombinant protein

LCP2, also known as lymphocyte cytosolic protein 2, is an intracellular docking protein with a single SH2 recognition domain. It is involved in T-cell antigen receptor mediated signaling. This protein is phosphorylated by ZAP70 leading to NF-AT and IL2 gene activation. Recombinant human LCP2 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for LCP2 recombinant protein

Signal Transduction

References

Siggs OM., et al, (2015) J Immunol. 194:2587-2595.; Danzer C., et al, (2016) Eur J Immunol. 46:2121-2136.

NCBI and Uniprot Product Information

• NCBI GI #: 5031855
• NCBI GeneID: 3937
• NCBI Accession #: NP_005556
• NCBI GenBank Nucleotide #: NM_005565.4
• UniProt Accession #: Q13094; Q53XV4; A8KA25
• Molecular Weight: 61.2kDa (542aa) 70-100KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: lymphocyte cytosolic protein 2
• NCBI Official Synonym Full Names: lymphocyte cytosolic protein 2
• NCBI Official Symbol: LCP2
• NCBI Official Synonym Symbols: SLP76; SLP-76
• NCBI Protein Information: lymphocyte cytosolic protein 2
• UniProt Protein Name: Lymphocyte cytosolic protein 2
• Protein Family: Larval cuticle protein
• UniProt Gene Name: LCP2
• UniProt Synonym Gene Names: SLP76

NCBI Description

This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

Uniprot Description

Involved in T-cell antigen receptor mediated signaling.