Keratin, type II cuticular Hb1 (KRT81) Recombinant Protein | KRT81 recombinant protein

Recombinant Human Keratin, type II cuticular Hb1 (KRT81)

Cat. Num. AAA1299943

• Gene Names: KRT81; HB1; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Keratin; type II cuticular Hb1 (KRT81); Recombinant Human Keratin; KRT81 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-505, Full length protein
• Sequence: MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC
• Sequence Length: 505

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KRT81 recombinant protein

This protein is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.

NCBI and Uniprot Product Information

• NCBI GI #: 169790853
• NCBI GeneID: 3887
• NCBI Accession #: NP_002272.2
• NCBI GenBank Nucleotide #: NM_002281.3
• UniProt Accession #: Q14533; Q14846; Q16274; Q17R48; Q8WU52; Q9BR74
• Molecular Weight: 54,928 Da
• NCBI Official Full Name: keratin, type II cuticular Hb1
• NCBI Official Synonym Full Names: keratin 81
• NCBI Official Symbol: KRT81
• NCBI Official Synonym Symbols: HB1; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1
• NCBI Protein Information: keratin, type II cuticular Hb1
• UniProt Protein Name: Keratin, type II cuticular Hb1
• Protein Family: Keratin
• UniProt Gene Name: KRT81
• UniProt Synonym Gene Names: KRTHB1; MLN137; K81; MLN 137; ghHb1

NCBI Description

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Uniprot Description

MiscellaneousThere are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).