Neurosin Recombinant Protein | KLK6 recombinant protein

Neurosin protein

• Applications: Western Blot
• Purity: > 85% pure
• Synonyms: Neurosin; Neurosin protein; Kallikrein 6 protein; Bssp protein; hK 6 protein; hK6 protein; Kallikrein 6 precursor protein; Kallikrein related peptidase 6 protein; Kallikrein6 protein; KLK 6 protein; Klk 7 protein; KLK 9 protein; KLK6 protein; Klk7 protein; KLK9 protein; MGC9355 protein; mGK 1 protein; mGK1 protein; Protease M protein; Protease serine 18 protein; Protease serine 9 protein; PRSS 18 protein; PRSS 9 protein; PRSS18 protein; PRSS9 protein; Serine protease 18 protein; Serine protease 9 protein; SP 59 protein; SP59 protein; Tissue kallikrein protein; TK protein; Zyme protein; KLK6 recombinant protein

• Host: Human
• Purity/Purification: > 85% pure
• Form/Format: Supplied in liquid form in 20mM HEPES, pH 7.0, 10% Glycerol
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 244

• Applicable Applications for KLK6 recombinant protein: Western Blot (WB)
• Protein Type: Recombinant
• Biological Significance: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Neurosin (KLK6), one of these, is a trypsin-like protease dominantly expressed in the human brain but also in a variety of other tissues. As measured by a sensitive quantitative assay in serum and cerebrospinal fluid (CSF), it may have value as a biomarker for identification and monitoring of Alzheimer?s disease (AD). It seems to be down regulated in serum and tissues of AD patients and may be involved in amyloid metabolism.
• Expression System: E Coli
• Preparation and Storage: Store at -80 degree C. Avoid frequent freeze/thaw cycles

Western Blot (WB)

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Related Product Information for KLK6 recombinant protein

Purified recombinant Neurosin protein

Product Categories/Family for KLK6 recombinant protein

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 1805493
• Molecular Weight: 51.8 kDa
• NCBI Official Full Name: neurosin
• UniProt Protein Name: Kallikrein-6
• Protein Family: Kallikrein
• UniProt Gene Name: KLK6
• UniProt Synonym Gene Names: PRSS18; PRSS9
• UniProt Entry Name: KLK6_HUMAN

Uniprot Description

KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Nucleolus; Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleoplasm; microtubule cytoskeleton; extracellular space; nuclear membrane; intercellular bridge; mitochondrion; endoplasmic reticulum; cytoplasm; nucleolus; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: myelination; collagen catabolic process; protein autoprocessing; central nervous system development; tissue regeneration; amyloid precursor protein metabolic process; regulation of cell differentiation; positive regulation of G-protein coupled receptor protein signaling pathway; response to wounding; hormone metabolic process; protein processing; proteolysis