Human kallikrein-related peptidase 14 ELISA Kit | KLK14 elisa kit
Human Kallikrein-14, KLK14 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
KLK14: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein type: Secreted; Protease; EC 3.4.21.-; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase activity
Biological Process: fertilization; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; epidermis morphogenesis; proteolysis
Research Articles on KLK14
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Product Notes
The Human KLK14 klk14 (Catalog #AAA934175) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA934175 ELISA Kit recognizes Human KLK14. It is sometimes possible for the material contained within the vial of "kallikrein-related peptidase 14, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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