Mouse kelch-like 25 (Drosophila) ELISA Kit | KLHL25 elisa kit
Mouse Ectoderm-neural cortex protein 2, KLHL25 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
KLHL25: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated)
Protein type: Unknown function
Cellular Component: cytoplasm
Biological Process: regulation of translation; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of translational initiation
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Product Notes
The Mouse KLHL25 klhl25 (Catalog #AAA9337186) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337186 ELISA Kit recognizes Mouse KLHL25. It is sometimes possible for the material contained within the vial of "kelch-like 25 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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