Human Kruppel-like factor 12 ELISA Kit | KLF12 elisa kit
Human Krueppel-like factor 12, KLF12 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
KLF12: Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 13q22
Cellular Component: nucleus
Molecular Function: DNA binding; metal ion binding; transcription factor activity; transcription corepressor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
Research Articles on KLF12
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Product Notes
The Human KLF12 klf12 (Catalog #AAA9331935) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331935 ELISA Kit recognizes Human KLF12. It is sometimes possible for the material contained within the vial of "Kruppel-like factor 12, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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