Rabbit KLF12 Polyclonal Antibody | anti-KLF12 antibody

KLF12 Rabbit Polyclonal

Cat. Num. AAA7600831

• Gene Names: KLF12; AP2REP; AP-2rep; HSPC122
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: KLF12; Polyclonal Antibody; KLF12 Rabbit Polyclonal; anti-KLF12 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 402

• Applicable Applications for anti-KLF12 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Kruppel-like factor 12
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7600831 (KLF12 Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 21071074
• NCBI GeneID: 11278
• NCBI Accession #: NP_009180.3
• NCBI GenBank Nucleotide #: NM_007249.4
• Molecular Weight: 33,250 Da
• NCBI Official Full Name: Krueppel-like factor 12
• NCBI Official Synonym Full Names: Kruppel like factor 12
• NCBI Official Symbol: KLF12
• NCBI Official Synonym Symbols: AP2REP; AP-2rep; HSPC122
• NCBI Protein Information: Krueppel-like factor 12
• UniProt Protein Name: Krueppel-like factor 12
• Protein Family: Krueppel-like factor
• UniProt Gene Name: KLF12
• UniProt Synonym Gene Names: AP2REP
• UniProt Entry Name: KLF12_HUMAN

NCBI Description

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

KLF12: Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: DNA binding; metal ion binding; protein binding; transcription corepressor activity; transcription factor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent