Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat kidney tissue slide using MBS7607530 (TK2 Antibody) at dilution of 1:100)
Rabbit anti-Mouse, Rat TK2 Polyclonal Antibody | anti-TK2 antibody
Anti-TK2 Antibody
Immunogen affinity purified
Immunogen affinity purified
IHC: 1:50-1:500
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat kidney tissue slide using MBS7607530 (TK2 Antibody) at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat kidney tissue slide using MBS7607530 (TK2 Antibody) at dilution of 1:100)
Western Blot (WB)
(mouse liver were subjected to SDS PAGE followed by western blot with MBS7607530 (TK2 antibody) at dilution of 1:1000)
Western Blot (WB)
(mouse liver were subjected to SDS PAGE followed by western blot with MBS7607530 (TK2 antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
Uniprot Description
TK2: Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs. Defects in TK2 are a cause of mitochondrial DNA depletion syndrome type 2 (MTDPS2). A disorder characterized primarily by childhood onset of muscle weakness associated with depletion of mtDNA in skeletal muscle. There is wide clinical variability; some patients have onset in infancy and show a rapidly progressive course with early death due to respiratory failure, whereas others have later onset of a slowly progressive myopathy. Belongs to the DCK/DGK family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.7.1.21; Kinase, other; Mitochondrial; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 16q22-q23.1
Cellular Component: mitochondrial matrix; mitochondrial inner membrane
Molecular Function: deoxycytidine kinase activity; thymidine kinase activity; ATP binding
Biological Process: deoxycytidine metabolic process; pyrimidine base metabolic process; nucleotide biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; deoxyribonucleotide metabolic process; thymidine metabolic process; pyrimidine nucleoside salvage; mitochondrial DNA replication; phosphorylation; deoxyribonucleoside monophosphate biosynthetic process
Disease: Mitochondrial Dna Depletion Syndrome 2 (myopathic Type)
Research Articles on TK2
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Product Notes
The TK2 tk2 (Catalog #AAA7607530) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TK2 Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TK2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:200-1:2000 IHC: 1:50-1:500. Researchers should empirically determine the suitability of the TK2 tk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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