KIR2DL5 Recombinant Protein | KIR2DL5A recombinant protein

KIR2DL5 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8122015

• Gene Names: KIR2DL5A; CD158F; KIR2DL5; KIR2DL5B; KIR2DL5.1; KIR2DL5.3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: KIR2DL5; KIR2DL5 Protein; Human; Recombinant (hFc Tag); Human KIR2DL5A Protein (Fc Tag); CD158F Protein; KIR2DL5.1 Protein; KIR2DL5.3 Protein; killer cell immunoglobulin like receptor; two Ig domains and long cytoplasmic tail 5A; KIR2DL5A recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-His240

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: His 22
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human KIR2DL5A (NP_065396.1)(Met1-His240) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for KIR2DL5A recombinant protein

Background: KIR2DL5A (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A) is a Protein Coding gene. The encoded protein belongs to the immunoglobulin superfamily. The most recently described member of the KIR family, KIR2DL5, is represented in human populations by at least four gene variants, whose exons differ by two to eight nucleotides. KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. KIR2DL5 is encoded by two paralogous genes displaying copy number variation and allelic polymorphism-KIR2DL5A and KIR2DL5B. Functional polymorphisms in both its promoter and its coding regions are critical for understanding the KIR2DL5 role in immunity and its importance for human health.

Product Categories/Family for KIR2DL5A recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

NCBI and Uniprot Product Information

• NCBI GI #: 11968154
• NCBI GeneID: 57292
• NCBI Accession #: NP_065396.1
• NCBI GenBank Nucleotide #: NM_020535.3
• UniProt Accession #: Q8N109
• Molecular Weight: 40,678 Da
• NCBI Official Full Name: killer cell immunoglobulin-like receptor 2DL5A
• NCBI Official Synonym Full Names: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
• NCBI Official Symbol: KIR2DL5A
• NCBI Official Synonym Symbols: CD158F; KIR2DL5; KIR2DL5B; KIR2DL5.1; KIR2DL5.3
• NCBI Protein Information: killer cell immunoglobulin-like receptor 2DL5A; killer-cell Ig-like receptor; killer cell immunoglobulin-like receptor KIR2DL5A; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5
• UniProt Protein Name: Killer cell immunoglobulin-like receptor 2DL5A
• Protein Family: Killer cell immunoglobulin-like receptor
• UniProt Gene Name: KIR2DL5A
• UniProt Synonym Gene Names: CD158F; CD158F1; KIR2DL5

NCBI Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.