KIR2DL1 recombinant protein

KIR2DL1, Recombinant, Human (p58 KIR, p58.1, CD158, cl-42, KIR-K6, NKAT1, NKR-K6, Killer Cell Immunoglobulin (Ig)-like Receptor)

Gene Names

KIR2DL1; NKAT; NKAT1; p58.1; CD158A; KIR221; KIR-K64

Purity

Highly Purified
95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

Synonyms

KIR2DL1; Recombinant; Human (p58 KIR; p58.1; CD158; cl-42; KIR-K6; NKAT1; NKR-K6; Killer Cell Immunoglobulin (Ig)-like Receptor); KIR2DL1 recombinant protein

Ordering
Cat. Num. AAA636295 For Research Use Only!

Host

E Coli

Purity/Purification

Highly Purified
95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

Form/Format

Supplied as a liquid in 25mM Tris-HCl, pH 7.5.

Sequence

MEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN

Preparation and Storage

-20 degree C
Stability: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for KIR2DL1 recombinant protein

An inhibitory Killer Cell Ig-like Receptor(KIR, previously called p58 KIR, p58.1, cl-42, NKAT1, or KIR-K6), which recognizes class I MHC molecules(HLA-Cw2, -Cw4, -Cw5, and Cw6). The extracellular domain of KIR2DL1 was over expressed as insoluble protein aggregates(inclusion bodies) Recombinant KIR2DL1 produced in E.Coli is a single,non-glycosylated polypeptide chain containing amino acids 1-202 and having a molecular mass of 22.2kD.

Product Categories/Family for KIR2DL1 recombinant protein

Molecular Biology; MB-Receptors

NCBI and Uniprot Product Information

NCBI GI #

93359503

NCBI GeneID

3802

UniProt Accession #

P43626; O43470; Q32WE6

Molecular Weight

22.2kD

NCBI Official Full Name

KIR2DL1

NCBI Official Synonym Full Names

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1

NCBI Official Symbol

KIR2DL1

NCBI Official Synonym Symbols

NKAT; NKAT1; p58.1; CD158A; KIR221; KIR-K64

NCBI Protein Information

killer cell immunoglobulin-like receptor 2DL1; NKAT-1; killer Ig receptor; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; killer inhibitory receptor 2-2-1; CD158 antigen-like family member A; natural killer-associated transcript 1; p58 NK cell inhibitory receptor NKR-K6; p58.1 MHC class-I-specific NK receptor; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11

UniProt Protein Name

Killer cell immunoglobulin-like receptor 2DL1

Protein Family

Killer cell immunoglobulin-like receptor

UniProt Gene Name

KIR2DL1

UniProt Synonym Gene Names

CD158A; NKAT1; NKAT-1

UniProt Entry Name

KI2L1_HUMAN

NCBI Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Uniprot Description

KIR2DL1: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: regulation of immune response; immune response; natural killer cell inhibitory signaling pathway

Research Articles on KIR2DL1

1. NK cells were isolated from peripheral blood and the lysis of KG1A and K562 cells by the NK cells was analyzed to investigate whether KIR2DL1 expression on NK cells would affect the cytotoxicity.

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Product Notes

The KIR2DL1 kir2dl1 (Catalog #AAA636295) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN. It is sometimes possible for the material contained within the vial of "KIR2DL1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.