Mouse kinesin family member 22 ELISA Kit | KIF22 elisa kit
Mouse Kinesin-like protein KIF22, KIF22 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
KIF22: Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Defects in KIF22 are the cause of spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2). A bone disease characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly. The most distinctive features for differential diagnosis of SEMDJL2 are the slender metacarpals and phalanges and the progressive degeneration of carpal bones; however, these 2 features are evident only in older children and young adults. The soft consistency of cartilage in the airways leads to laryngotracheomalacia with proneness to respiratory obstruction and inspiratory stridor in infancy and childhood. Belongs to the kinesin-like protein family.
Protein type: Motor; Microtubule-binding
Cellular Component: nucleoplasm; kinesin complex; microtubule; cytoskeleton; focal adhesion; cytoplasm; spindle; nucleus; chromatin
Molecular Function: DNA binding; microtubule binding; ATPase activity; nucleotide binding; microtubule motor activity; ATP binding
Biological Process: sister chromatid cohesion; DNA repair; mitotic metaphase plate congression; microtubule-based movement
Research Articles on KIF22
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Product Notes
The Mouse KIF22 kif22 (Catalog #AAA9341765) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341765 ELISA Kit recognizes Mouse KIF22. It is sometimes possible for the material contained within the vial of "kinesin family member 22, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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