Human kinesin family member 13A ELISA Kit | KIF13A elisa kit
Human Kinesin-like protein KIF13A, KIF13A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Description
KIF13A: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 6p23
Cellular Component: Golgi membrane; microtubule; kinesin complex; centrosome; trans-Golgi network membrane; endosome membrane; midbody
Molecular Function: protein binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding
Biological Process: intracellular protein transport; melanosome organization and biogenesis; metabolic process; Golgi to plasma membrane protein transport; endosome to lysosome transport; cytokinesis; microtubule-based movement
Research Articles on KIF13A
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Product Notes
The Human KIF13A kif13a (Catalog #AAA9337753) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337753 ELISA Kit recognizes Human KIF13A. It is sometimes possible for the material contained within the vial of "kinesin family member 13A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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