KIF11 recombinant protein

Recombinant Human KIF11 protein, N- His Tag

Cat. Num. AAA157522

• Gene Names: KIF11; EG5; HKSP; KNSL1; MCLMR; TRIP5
• Purity: >90% as determined by SDS-PAGE
• Synonyms: KIF11; Recombinant Human KIF11 protein; N- His Tag; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; KIF11 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS, pH 6.8, 0.02% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Human
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
• Construction: A DNA sequence encoding the Human KIF11 (Met1-Lys368) was fused with the N-terminal His Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

Product Categories/Family for KIF11 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 13699824
• NCBI GeneID: 3832
• NCBI Accession #: NP_004514.2
• NCBI GenBank Nucleotide #: NM_004523.3
• UniProt Accession #: P52732; Q15716; Q5VWX0; A0AV49; B2RMV3
• Molecular Weight: 119,159 Da
• NCBI Official Full Name: kinesin-like protein KIF11
• NCBI Official Synonym Full Names: kinesin family member 11
• NCBI Official Symbol: KIF11
• NCBI Official Synonym Symbols: EG5; HKSP; KNSL1; MCLMR; TRIP5
• NCBI Protein Information: kinesin-like protein KIF11; TRIP-5; kinesin-like protein 1; TR-interacting protein 5; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; thyroid receptor-interacting protein 5
• UniProt Protein Name: Kinesin-like protein KIF11
• Protein Family: Kinesin-like protein
• UniProt Gene Name: KIF11
• UniProt Synonym Gene Names: EG5; KNSL1; TRIP5; TR-interacting protein 5; TRIP-5
• UniProt Entry Name: KIF11_HUMAN

NCBI Description

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

Uniprot Description

KIF11: a cytoskeletal protein that belongs to the kinesin-like protein family. BimC subfamily. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Plays a role in chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Phosphorylation regulates its association with the spindle apparatus.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 10q24.1

Cellular Component: spindle pole; kinesin complex; microtubule; membrane; spindle microtubule; cytoplasm; spindle; cytosol

Molecular Function: plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; protein complex binding; microtubule motor activity; protein kinase binding; ATP binding

Biological Process: mitosis; mitotic spindle organization and biogenesis; mitotic centrosome separation; cell division; metabolic process; regulation of mitotic centrosome separation; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; spindle organization and biogenesis; microtubule-based movement; chromosome segregation

Disease: Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Mental Retardation